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One-pot three component condensation reaction in water: an efficient and improved procedure for the synthesis of furo[2,3-d]pyrimidine-2,4(1H,3H)-diones

✍ Scribed by Ahmad Shaabani; Mohammad Bagher Teimouri; Hamid Reza Bijanzadeh

Publisher: Elsevier Science
Year: 2002
Tongue: French
Weight: 159 KB
Volume: 43
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)02260-8

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✦ Synopsis

The environment-friendly three component condensation reactions of N,N%-dimethylbarbituric acid, 4-nitrobenzaldehyde and alkyl or aryl isocyanides to afford the corresponding furo[2,3-d]pyrimidine-2,4(1H,3H)-diones, in water, in high yields after several minutes are reported.

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