𝔖 Bobbio Scriptorium
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On the Mechanism of the Metallo-β-lactamase from Bacteroides fragilis †

✍ Scribed by Wang, Zhigang; Fast, Walter; Benkovic, Stephen J.


Book ID
125838877
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
287 KB
Volume
38
Category
Article
ISSN
0006-2960

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## Abstract The metallo‐β‐lactamases require zinc or cadmium for hydrolyzing β‐lactam antibiotics and are inhibited by mercurial compounds. To date, there are no clinically useful inhibitors of this class of enzymes. The crystal structure of the Zn^2+^‐bound enzyme from __Bacteroides fragilis__ con