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Protonation State of Asp120 in the Binuclear Active Site of the Metallo-β-Lactamase from Bacteroides fragilis

✍ Scribed by Dal Peraro, Matteo; Vila, Alejandro J.; Carloni, Paolo


Book ID
118137986
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
146 KB
Volume
42
Category
Article
ISSN
0020-1669

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## Abstract The metallo‐β‐lactamases require zinc or cadmium for hydrolyzing β‐lactam antibiotics and are inhibited by mercurial compounds. To date, there are no clinically useful inhibitors of this class of enzymes. The crystal structure of the Zn^2+^‐bound enzyme from __Bacteroides fragilis__ con