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On the functions of lithium: The mood stabilizer

✍ Scribed by Barkur S. Shastry

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
289 KB
Volume
19
Category
Article
ISSN
0265-9247

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✦ Synopsis

Lithium, despite its simple structure, has numerous biological effects. It also has a remarkable therapeutic effect in the prophylactic treatment of manic depression, and is finding a role in controlling aggressive and self-mutilating behavior. The special feature of lithium is that it only acts on overactive systems to bring them back to normal, without affecting the stable system. The mechanisms of action of this simple cation are still largely unknown although the inositol depletion theory is the most widely accepted model. A recent paper(') described a different molecular mechanism for its effect on development, which may also explain its action in manic depression.

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