𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Effects of mood-stabilizing drugs on the peripheral serotonin transporter

✍ Scribed by D. Marazziti; A. Rotondo; A. Lenzi; S. Presta; S. Silvestri; G. B. Cassano

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
393 KB
Volume
7
Category
Article
ISSN
0885-6222

No coin nor oath required. For personal study only.

✦ Synopsis

We studied the effect of lithium (L), carbamazepine (CBZ), valproic acid (VA), verapamil (VP) and nifedipine (NF) on the specific binding of 3H-imipramine (3H-IMI) to platelet membranes, as compared with clomipramine (CLO). The results showed that VP, NF and CLO exerted a concentration-dependent inhibition on the IMI binding; CLO had the most potent inhibitory effect. No effect was observed with L. CBZ or VA. These results suggest that while VP and NF interact with the 5-HT transporter complex, L, CBZ and VA do not. Therefore, their effective (or suggested) mood-stabilizing effects are likely to be related to different mechanisms.

KEY woms-Mood disorders, mood-stabilizing drugs, Ca' channel-blockers, serotonin, platelets, imipramine binding.

πŸ“œ SIMILAR VOLUMES

Stimulatory effects of the soy phytoestr
Stimulatory effects of the soy phytoestrogen genistein on noradrenaline transporter and serotonin transporter activity
✍ Yumiko Toyohira; Susumu Ueno; Masato Tsutsui; Hideaki Itoh; Norio Sakai; Naoaki πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 285 KB

## Abstract We examined the effects of genistein, one of the major soy phytoestrogens, on the activity of noradrenaline transporter (NAT) and serotonin transporter. Treatment with genistein (10 nM–10 μM) for 20 min stimulated [^3^H]noradrenaline (NA) uptake by SK‐N‐SH cells. Genistein also stimulat

Sex influences the effect of a lifelong
Sex influences the effect of a lifelong increase in serotonin transporter function on cerebral metabolism
✍ Neil Dawson; Linda Ferrington; Henry J. Olverman; Anthony J. Harmar; Paul A. T. πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 223 KB πŸ‘ 1 views

## Abstract Polymorphic variation in the human serotonin transporter (SERT; 5‐HTT) gene resulting in a lifelong increase in SERT expression is associated with reduced anxiety and a reduced risk of affective disorder. Evidence also suggests that sex influences the effect of this polymorphism on affe

The effects of the dopamine and serotoni
The effects of the dopamine and serotonin transporter polymorphisms on clinical features and treatment response in geriatric depression: a pilot study
✍ Helen Lavretsky; Prabha Siddarth; Anand Kumar; Charles F. Reynolds III πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 85 KB πŸ‘ 2 views

## Abstract ## Background The authors examined the role of dopamine and serotonin transporter genetic polymorphisms in clinical and cognitive features of subjects with late‐life depression, and in preferential treatment response to the combination of methylphenidate and citalopram. ## Method The

Effect of cationized gelatins on the par
Effect of cationized gelatins on the paracellular transport of drugs through caco-2 cell monolayers
✍ Toshinobu Seki; Hiroshi Kanbayashi; Tomonobu Nagao; Sumio Chono; Yasuhiko Tabata πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 163 KB

Cationized gelatins, candidate absorption enhancers, were prepared by addition of ethylenediamine or spermine to gelatin and the effects of the resulting ethylenediaminated gelatin (EG) and sperminated gelatin (SG) on the paracellular transport of 5(6)-carboxyfluorescein (CF), FITC-dextran-4 (FD4),