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The effect of vigabatrin on cognitive function and mood

✍ Scribed by J. B. Dijkstra; A. M. McGuire; M. R. Trimble


Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
386 KB
Volume
7
Category
Article
ISSN
0885-6222

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✦ Synopsis


Abstract

Cognitive function and mood have been assessed in nine patients started on vigabatrin as additional therapy to their regular anticonvulsants. Psychological tests were given at baseline (S1) and at 4 weeks (S2) after starting treatment. A comparison group of nine patients on stable therapy was tested at the same time intervals. In particular, tasks with minimal or no motor components were used. Mood was rated with the Beck Depression Inventory. The vigabatrin group scored significantly higher on a task of attention and concentration at S2. This was not related to change of seizure frequency or serum levels of other anticonvulsants. No effects were observed on mood.


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