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On the biosynthesis of moenocinol, the lipid part of the moenomycin antibiotics

✍ Scribed by Urs Schuricht; Lothar Hennig; Matthias Findeisen; Peter Welzel


Book ID
108379702
Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
121 KB
Volume
41
Category
Article
ISSN
0040-4039

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The biosynthesis of moenocinol, the lipi
✍ Urs Schuricht; Lothar Hennig; Matthias Findeisen; Peter Welzel; Duilio Arigoni πŸ“‚ Article πŸ“… 2001 πŸ› Elsevier Science 🌐 French βš– 83 KB

The C 25 terpenoid moenocinol is suggested to originate from a farnesyl precursor and geranyl pyrophosphate. The new mechanism is in accord with all previous feeding experiments. Feeding of [2,[5][6][7][8][9][10][11][12][13] C 2 ]-labeled 1-deoxy-D-xylulose proves how the two units are joined in the

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## Abstract __Upon feeding of [2‐__^__13__^__C,4‐__^__2__^__H]‐1‐deoxy‐D‐xylulose to__ Streptomyces ghanaensis, __the deuterium label was retained exclusively at positions C‐7 and C‐17 in the moenocinol part of the moenomycin antibiotics. This result vindicates the hypothesis that the C__~__25__~ _

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Moenomycin A is an amphiphilic phosphoglycolipid antibiotic that interferes with the transglycosylation step in peptidoglycan biosynthesis. The antibiotic consists of a branched pentasaccharide moiety, connected to the moenocinol lipid via a glycerophosphate linker. We have previously described the