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The biosynthesis of moenocinol, the lipid part of the moenomycin antibiotics

✍ Scribed by Urs Schuricht; Lothar Hennig; Matthias Findeisen; Peter Welzel; Duilio Arigoni

Publisher: Elsevier Science
Year: 2001
Tongue: French
Weight: 83 KB
Volume: 42
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)00569-x

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✦ Synopsis

The C 25 terpenoid moenocinol is suggested to originate from a farnesyl precursor and geranyl pyrophosphate. The new mechanism is in accord with all previous feeding experiments. Feeding of [2,[5][6][7][8][9][10][11][12][13] C 2 ]-labeled 1-deoxy-D-xylulose proves how the two units are joined in the course of the moenocinol biosynthesis.

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