On teratogenic effects of pilocarpine in chick development
β Scribed by Landauer, Walter
- Publisher
- John Wiley and Sons
- Year
- 1953
- Tongue
- English
- Weight
- 722 KB
- Volume
- 122
- Category
- Article
- ISSN
- 0022-104X
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β¦ Synopsis
THREE FIGURES
A number of chemical compounds are known which, when injected into the yolk sac of developing chicken eggs, call forth rumplessness (i.e., partial or complete absence of the tail skeleton and associated parts) during early stages of incubation and, somewhat later, produce a syndrome of malformations involving the facial skeleton and the posterior extremities. The most intensively studied of these substances are insulin and boric acid. Both compounds have similar gross morphological effects on tail development (though there may be differences in detail), but the incidence of rumplessness is
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Injection of minute amounts of actinomycin D into the yolk sac of chick embryos during the second day of incubation is capable of inducing anomalous development of the axial skeleton (Pierro, '61). Abnormal embryos are classified as either trunkless or rumpless. Rumpless embryos lack a pygostyle and
## Abstract ## BACKGROUND Bisβdiamine induces conotruncal anomalies and disproportional ventricular development in rat embryos when administered to the mother. To evaluate the mechanisms of disproportional ventricular development in the anomalous heart, we analyzed the morphology of the embryonic