๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

The teratogenic effect of phenobarbital on the embryonic chick heart

โœ Scribed by Toshio Nishikawa; Harold J. Bruyere Jr.; Yasuo Takagi; Enid F. Gilbert; Rumiko Matsuoka

Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
440 KB
Volume
6
Category
Article
ISSN
0260-437X

No coin nor oath required. For personal study only.

โœฆ Synopsis

Phenobarbital was observed to produce cardiovascular malformations in embryonic chicks. Malformations included simple ventricular septal defect, ventricular septal defect associated with dextroposition of the aorta, double outlet right ventricle, and several types of aortic arch anomalies. Embryos were exposed to phenobarbital at doses of 1-25 pmol on day 4 of incubation (Hamburger-Hamilton developmental stage 24). Doses equal to and greater than 5 pmol phenobarbital (26 mg/kg egg) significantly increased the frequency of embryos with cardiovascular malformations compared with lesser doses and with saline. A significant reduction in heart rate and abnormal rhythm of the heart were observed in embryos treated with teratogenic doses of phenobarbital. No arrhythmia nor significant changes in heart rate were observed in embryos exposed to subteratogenic doses of phenobarbital or to saline.

๐Ÿ“œ SIMILAR VOLUMES

Atropine effects on the embryonic rat he
Atropine effects on the embryonic rat heart
โœ Hall, E. K. ๐Ÿ“‚ Article ๐Ÿ“… 1959 ๐Ÿ› Wiley (John Wiley & Sons) ๐ŸŒ English โš– 475 KB ๐Ÿ‘ 1 views

## T W O FIGURES There is diversity of opinion as to the nature of action of atropine on cardiac muscle. It is stated in some texts that atropine has slight and insignificant direct effects, in others. that small doses stimulate but that large doses depress. Nearly all authors agree that, in block

Teratogenic effects of bis-diamine on ea
Teratogenic effects of bis-diamine on early embryonic rat heart: An in vitro study
โœ Nishijima, Setsuko ;Nakagawa, Masao ;Fujino, Hidetoshi ;Hanato, Takashi ;Okamoto ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 449 KB ๐Ÿ‘ 2 views

Background: Bis-diamine induces cardiac defects, including conotruncal anomalies in rat embryos when the agent is administered to the mother. To evaluate the teratogenic effects and mechanism of bis-diamine, we performed morphological and immunohistochemical analyses of early rat embryos cultured in