✦ LIBER ✦

Teratogenic action of actinomycin D in the embryonic chick II. Early development

✍ Scribed by Pierro, Louis J.

Publisher: John Wiley and Sons
Year: 1961
Tongue: English
Weight: 660 KB
Volume: 148
Category: Article
ISSN: 0022-104X
DOI: 10.1002/jez.1401480306

No coin nor oath required. For personal study only.

✦ Synopsis

Injection of minute amounts of actinomycin D into the yolk sac of chick embryos during the second day of incubation is capable of inducing anomalous development of the axial skeleton (Pierro, '61). Abnormal embryos are classified as either trunkless or rumpless. Rumpless embryos lack a pygostyle and free caudal vertebrae, and usually some synsacral vertebrae as well. Among the trunkless embryos, axial deficiencies extend to the lumbar and even thoracic levels.

A study of early development in actinomycin D treated embryos was undertaken in order to obtain information concerning the developmental basis of the teratogenic effects of the antibiotic. Attention was directed to ( 1 ) the detection of the earliest morphological aberrations, and ( 2 ) the translation of these aberrations into trunklessness and rumplessness. 1 Contribution no. 65 of the Institute of Cellular 24 1 Biology.

📜 SIMILAR VOLUMES

Teratogenic action of actinomycin D in t

Teratogenic action of actinomycin D in the embryonic chick

✍ Pierro, Louis J. 📂 Article 📅 1961 🏛 John Wiley and Sons 🌐 English ⚖ 646 KB

Early development of the oligodendrocyte

Early development of the oligodendrocyte in the embryonic chick metencephalon

✍ Katsuhiko Ono; Hajime Fujisawa; Shigeki Hirano; Masao Norita; Toshiko Tsumori; Y 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 877 KB

It has been demonstrated that the spinal cord oligodendrocytes in the vertebrates arise in the ventral ventricular zone adjacent to the floor plate in their early development. Because of the similarities of basic structures in the spinal cord and metencephalon, it is probable that the mode of early

Sucrase activity in the intestine of the

Sucrase activity in the intestine of the chick: Normal development and influence of hydrocortisone, actinomycin D, cycloheximide, and puromycin

✍ Brown, Kathren Mortenson 📂 Article 📅 1971 🏛 John Wiley and Sons 🌐 English ⚖ 955 KB

Sucrase activity i n the intestine of the chick embryo increases to a pre-hatching maximum at 19 days. A significant decrease i n activity occurs by 20 days, followed by rapid increases i n the jejunum and the ileum after hatching, while duodenal activity continues to decrease. The injection of hydr

Comparative analysis of the development

Comparative analysis of the development of the lizard, Liolaemus tenuis tenuis. II. A series of normal postlaying stages in embryonic development

✍ D. Lemus; J. Illanes; M. Fuenzalida; Y. Paz De La Vega; M. Garcia 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 English ⚖ 873 KB

## Abstract In this work, we have completed a study of the development of the ovoviviparous lizard __Liolaemus tenuis tenuis__. Ovoviviparity in this lizard is a condition in which eggs are retained within the reproductive duct for about 60 days. During this period the phases of segmentation, gastr

Evaluation of the reproductive and devel

Evaluation of the reproductive and developmental safety of cysteamine in the rat: Effects on female reproduction and early embryonic development

✍ Assadi, F. K.; Mullin, J. J.; Beckman, D. A. 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 67 KB 👁 2 views

Cystinosis is an autosomal recessive metabolic disease in which the amino acid cystine accumulates in lysosomes due to a defect in lysosomal cystine transport. Cystinosis in infancy is associated with poor growth, muscle wastage, and death at about age 10 due to kidney failure. Treatment with cystea