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On pyrrolidine derivatives I. An efficient synthesis of 3-substituted (2S,5S)-pyrrolidine-2, 5-dicarboxylic acids

✍ Scribed by Tsunetoshi Honma; Yukio Tada; Ikuo Adachi; Kikuo Igarashi


Book ID
112129264
Publisher
Journal of Heterocyclic Chemistry
Year
1989
Tongue
English
Weight
472 KB
Volume
26
Category
Article
ISSN
0022-152X

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Organocatalytic Direct Asymmetric Mannic
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## Abstract The direct one‐pot three‐component asymmetric Mannich reactions of hydroxyacetone with anilines and benzaldehydes in the presence of (2__S__,5__S__)‐pyrrolidine‐2,5‐dicarboxylic acid afforded __syn__‐1,2‐amino alcohols in good‐to‐excellent yields (64% –95%) and up to 96% __ee__.