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(2S,5S)-Pyrrolidine-2,5-dicarboxylic Acid, an Efficient Chiral Organocatalyst for Direct Aldol Reactions.

✍ Scribed by Qing Gu; Xiao-Fei Wang; Lei Wang; Xin-Yan Wu; Qi-Lin Zhou


Publisher
John Wiley and Sons
Year
2006
Weight
26 KB
Volume
37
Category
Article
ISSN
0931-7597

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Organocatalytic Direct Asymmetric Mannic
✍ Qing GU; Jing-Jing GONG; Jin FENG; Xin-Yan WU; Qi-Lin ZHOU πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 71 KB πŸ‘ 2 views

## Abstract The direct one‐pot three‐component asymmetric Mannich reactions of hydroxyacetone with anilines and benzaldehydes in the presence of (2__S__,5__S__)‐pyrrolidine‐2,5‐dicarboxylic acid afforded __syn__‐1,2‐amino alcohols in good‐to‐excellent yields (64% –95%) and up to 96% __ee__.