Design of a Binaphthyl-Based Axially Chiral Amino Acid as an Organocatalyst for Direct Asymmetric Aldol Reactions.
β Scribed by Taichi Kano; Osamu Tokuda; Jun Takai; Keiji Maruoka
- Publisher
- John Wiley and Sons
- Year
- 2006
- Weight
- 43 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0931-7597
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract **Amino sulfonamide catalyst**: A distal proton of the axially chiral amino sulfonamide (__S__)β**1** realized the opposite diastereoselectivity in Mannich and crossβaldol reactions compared with that observed in prolineβcatalyzed reactions. The reactions catalyzed by (__S__)β**1** proc
## Abstract **The moderate nucleophilicity** of the axially chiral amino sulfonamide (__S__)β**1** suppresses the problematic side reactions, including aldol reactions, in the asymmetric Mannich reaction of NβBocβprotected imines with aldehydes. The corresponding adducts are obtained in good yield