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Design of an Axially Chiral Amino Acid with a Binaphthyl Backbone as an Organocatalyst for a Direct Asymmetric Aldol Reaction.

✍ Scribed by Taichi Kano; Jun Takai; Osamu Tokuda; Keiji Maruoka

Publisher: John Wiley and Sons
Year: 2005
Weight: 20 KB
Volume: 36
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200538042

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## Abstract **The moderate nucleophilicity** of the axially chiral amino sulfonamide (__S__)‐**1** suppresses the problematic side reactions, including aldol reactions, in the asymmetric Mannich reaction of N‐Boc‐protected imines with aldehydes. The corresponding adducts are obtained in good yield