𝔖 Bobbio Scriptorium
✦   LIBER   ✦

On-line recovery of trimeprazine enantiomers following chiral separation by reversed-phase high-performance liquid chromatography using a β-cyclodextrin-containing mobile phase

✍ Scribed by A.D. Cooper; T.M. Jefferies

Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
282 KB
Volume
8
Category
Article
ISSN
0731-7085

No coin nor oath required. For personal study only.

✦ Synopsis

A procedure is described which allows the on-line recovery of enantiomers following semi-preparative chiral separation by RP-HPLC using beta-cyclodextrin in the mobile phase. By this method, the phenothiazine antihistamine trimeprazine (I) was resolved into its antipodes at greater than 95% optical purity at a throughput of more than 1 mg of each enantiomer per hour, using 4 mm i.d. columns. The recovered trimeprazine was found to be free from cyclodextrin.

📜 SIMILAR VOLUMES

Enantiomeric separation of d-/l-norepine
Enantiomeric separation of d-/l-norepinephrine and -epinephrine by high-performance liquid chromatography with a β-cyclodextrin type chiral stationary phase
✍ Takeshi Fukushima; Katsuhisa Murayama; Tomofumi Santa; Hiroshi Homma; Kazuhiro I 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 61 KB 👁 2 views

Enantiomeric separation of d-/l-norepinephrine (NE) and d-/l-epinephrine (E) was investigated with various mobile phases by high-performance liquid chromatography using a ␤-cyclodextrin type chiral stationary phase as a chiral column. The mobile phase of 2.5 M phosphate buffer (pH 3.0) gave separati