Modified nucleotides can be incorporated site specifically into RNA by the use of total chemical synthesis as well as by use of a variety of recombinant RNA techniques. The range of nucleotide analogues includes modifications to base, sugar, and phosphate for structure-function analysis and for cros
Oligoribonucleotides with Functionalized Nucleobases as New Modifiers of Biopolymers
β Scribed by M. Repkova; M. Meshchaninova; D. Pyshnyi; A. Venyaminova
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 59 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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For the efficient synthesis of oligoribonucleotides by the 5'-O-(4,4'-dimethoxytrityl) phosphoramidite approach, the 2'-O-[1-(benzyloxy)ethyl]acetals 56 Β± 67 were investigated. Studies with the 2'-O-[1-(benzyloxy)ethyl]-5'-O-(dimethoxytrityl)ribonucleoside 3'-phosphoramidites 56 Β± 59 gave, however,
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