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Oligonucleotide Analogues with a “Nucleobase-Including Backbone”. Part 10. Design, Synthesis, and Association of Ether-Linked Dimers.

✍ Scribed by Andrew John Matthews; Punit Kumar Bhardwaj; Andrea Vasella

Publisher
John Wiley and Sons
Year
2004
Weight
7 KB
Volume
35
Category
Article
ISSN
0931-7597

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Oligonucleotide Analogues with a ‘Nucleo
Oligonucleotide Analogues with a ‘Nucleobase-Including Backbone’. Part 10 : Design, Synthesis, and Association of Ether-Linked Dimers
✍ Andrew John Matthews; Punit Kumar Bhardwaj; Andrea Vasella 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 German ⚖ 493 KB

## Abstract The dinucleoside analogues **24, 25, 28**–**30**, and **33** associate in CDCl~3~ solution. Association constants, as determined from the concentration‐dependent chemical shift for HN(3) of the uridine moiety and from thermodynamic parameters, range from 265 M^−1^ (**33**) to 3220 M^−1