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Oligonucleotide Analogues with Integrated Bases and Backbone. Part 16. Synthesis and Association of Ethylene-Linked Self-Complementary Dimers.

✍ Scribed by Xiaomin Zhang; Bruno Bernet; Andrea Vasella


Publisher
John Wiley and Sons
Year
2007
Weight
11 KB
Volume
38
Category
Article
ISSN
0931-7597

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πŸ“œ SIMILAR VOLUMES


Oligonucleotide Analogues with Integrate
✍ Xiaomin Zhang; Bruno Bernet; Andrea Vasella πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 German βš– 331 KB

The self-complementary, ethylene-linked U\*[c a ]A ( \* ) dinucleotide analogues 8, 10, 12, 14, 16, and 18, and the sequence-isomeric A\*[c a ]U ( \* ) analogues 20, 22, 24, 26, 28, and 30 were obtained by Pd/Ccatalyzed hydrogenation of the corresponding, known ethynylene-linked dimers. The associat

Oligonucleotide Analogues with Integrate
✍ Xiaomin Zhang; Bruno Bernet; Andrea Vasella πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 German βš– 510 KB

The self-complementary (Z)-configured U\*[c e ]A ( \* ) dinucleotide analogues 6, 8, 10, 12, 14, and 16, and the A\*[c e ]U ( \* ) dimers 19, 21, 23, 25, 27, and 29 were prepared by partial hydrogenation of the corresponding ethynylene linked dimers. Photolysis of 14 led to the (E)-alkene 17. These

Oligonucleotide Analogues with Integrate
✍ Xiaomin Zhang; Bruno Bernet; Andrea Vasella πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 German βš– 637 KB

## Abstract The self‐complementary tetrameric propargyl triols **8, 14, 18**, and **21** were synthesized to investigate the duplex formation of self‐complementary, ethynylene‐linked UUAA, AAUU, UAUA, and AUAU analogues with integrated bases and backbone (ONIBs). The linear synthesis is based on re

Oligonucleotide Analogues with Integrate
✍ Anne Ritter; Daniel Egli; Bruno Bernet; Andrea Vasella πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 German βš– 737 KB

The formation of cyclic duplexes (pairing) of known oxymethylene-linked self-complementary U\*[o]A ( \* ) dinucleosides contrasts with the absence of pairing of the ethylene-linked U\*[c a ]A ( \* ) analogues. The origin of this difference, and the expected association of U\*[x]A ( \* ) and A\*[x]U