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Oligonucleosides with a Nucleobase-Including Backbone, Part 3, Synthesis of Acetyleno-Linked Adenosine Dimers

โœ Scribed by Hiroki Gunji; Andrea Vasella


Publisher
John Wiley and Sons
Year
2000
Tongue
German
Weight
222 KB
Volume
83
Category
Article
ISSN
0018-019X

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Oligonucleosides with a Nucleobase-Inclu
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## Abstract In contradistinction to the corresponding __Grignard__ reagent, bis[(trimethylsilyl)ethynyl]zinc reacted with the 5โ€ฒโ€oxoadenosine **3** diastereoselectively to the __ฮฒ__โ€Dโ€__allo__โ€heptโ€6โ€ynofuranosyladenine **5**. Lithiation/iodination of the monomeric propargyl alcohol **5** and of th