ChemInform Abstract: Oligonucleosides with a Nucleobase-Including Backbone. Part 4. A Convergent Synthesis of Ethynediyl-Linked Adenosine Tetramers.
✍ Scribed by Hiroki Gunji; Andrea Vasella
- Publisher
- John Wiley and Sons
- Year
- 2001
- Weight
- 25 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0931-7597
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## Abstract In contradistinction to the corresponding __Grignard__ reagent, bis[(trimethylsilyl)ethynyl]zinc reacted with the 5′‐oxoadenosine **3** diastereoselectively to the __β__‐D‐__allo__‐hept‐6‐ynofuranosyladenine **5**. Lithiation/iodination of the monomeric propargyl alcohol **5** and of th
## Abstract A linear and a convergent synthesis of uridine‐derived backbone‐base‐dedifferentiated (backbone including) oligonucleotide analogues were compared. The __Sonogashira__ cross‐coupling of the alkyne 1 and the iodide 2 gave the dimer 4 that was __C__‐desilylated and again coupled with 2 to