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Oligonucleosides with a Nucleobase-Including Backbone; Synthesis and Self-Association of Novel Dinucleotide Analogues.

✍ Scribed by Andrew J. Matthews; Punit K. Bhardwaj; Andrea Vasella

Publisher: John Wiley and Sons
Year: 2003
Weight: 127 KB
Volume: 34
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200331229

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## Abstract The dinucleoside analogues **24, 25, 28**–**30**, and **33** associate in CDCl~3~ solution. Association constants, as determined from the concentration‐dependent chemical shift for HN(3) of the uridine moiety and from thermodynamic parameters, range from 265 M^−1^ (**33**) to 3220 M^−1