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Oligodeoxynucleotide-directed cleavage and repair of a single-stranded vector: A method of site-specific mutagenesis

✍ Scribed by Delin Zhu

Book ID: 107714671
Publisher: Elsevier Science
Year: 1989
Tongue: English
Weight: 757 KB
Volume: 177
Category: Article
ISSN: 0003-2697
DOI: 10.1016/0003-2697(89)90025-0

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## Abstract ## Background Targeted gene repair is an attractive method to correct point‐mutated genes at their natural chromosomal sites, but it is still rather inefficient. As revealed by earlier studies, successful gene correction requires a productive interaction of the repair molecule with the