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OFF–off rebound dyskinesia in subthalamic nucleus deep brain stimulation of Parkinson's disease

✍ Scribed by Matthew A. Brodsky; Penelope Hogarth; John G. Nutt

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
143 KB
Volume
21
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

A 61‐year‐old man with Parkinson's disease (PD), motor fluctuations, and dyskinesias underwent bilateral implantation of deep brain stimulation (DBS) electrodes in the subthalamic nucleus (STN). One month after surgery, DBS was optimized to bilateral monopolar settings at the most proximal electrode just superior to the STN, which improved motor fluctuations and dyskinesias. At several postoperative evaluations off medications overnight, both stimulators were turned off and within 60 seconds he developed severe dyskinesias. When the stimulators were turned back on, the dyskinesias soon resolved. This article is a first report of a unique pattern of rebound‐type dyskinesia that occurred in the off medication state produced by stopping STN DBS. © 2006 Movement Disorder Society

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