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Addiction in Parkinson's disease: Impact of subthalamic nucleus deep brain stimulation

✍ Scribed by Tatiana Witjas; Christelle Baunez; Jean Marc Henry; Marie Delfini; Jean Regis; André Ali Cherif; Jean Claude Peragut; Jean Philippe Azulay

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
60 KB
Volume
20
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

In Parkinson's disease, dopamine dysregulation syndrome (DDS) is characterized by severe dopamine addiction and behavioral disorders such as manic psychosis, hypersexuality, pathological gambling, and mood swings. Here, we describe the case of 2 young parkinsonian patients suffering from disabling motor fluctuations and dyskinesia associated with severe DDS. In addition to alleviating the motor disability in both patients, subthalamic nucleus (STN) deep brain stimulation greatly reduced the behavioral disorders as well as completely abolished the addiction to dopaminergic treatment. Dopaminergic addiction in patients with Parkinson's disease, therefore, does not constitute an obstacle to high‐frequency STN stimulation, and this treatment may even cure the addiction. © 2005 Movement Disorder Society

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