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Oestrogens Prevent Loss of Dopamine Transporter (DAT) and Vesicular Monoamine Transporter (VMAT2) in Substantia Nigra of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Mice

✍ Scribed by S. Jourdain; M. Morissette; N. Morin; T. Di Paolo


Book ID
108869647
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
258 KB
Volume
17
Category
Article
ISSN
0953-8194

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## Abstract Administration of the neurotoxicant 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) to C57BL/6 mice targets nigrostriatal dopaminergic neurons, leading to cell death and the depletion of striatal dopamine. After MPTP lesioning in young adult mice, surviving nigrostriatal dopaminergi