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Increase in bax expression in substantia nigra following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment of mice

✍ Scribed by Imam Hassouna; Hannes Wickert; Manfred Zimmermann; Frank Gillardon


Book ID
116125401
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
338 KB
Volume
204
Category
Article
ISSN
0304-3940

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## Abstract In 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) models of Parkinson's disease (PD), dopaminergic (DA) neurons have been shown to die by apoptosis. Moreover, recent postmortem and in vitro results have indicated that apoptotic cell death induced by 1‐methyl‐4‐phenylpyridinium (MPP