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Octreotide potentiates PKC-dependent vasoconstrictors in portal-hypertensive and control rats

✍ Scribed by Reiner Wiest; Ming–Hung Tsai; Roberto J. Groszmann

Book ID
119756168
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
273 KB
Volume
120
Category
Article
ISSN
0016-5085

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Long-term octreotide treatment prevents
Long-term octreotide treatment prevents vascular hyporeactivity in portal-hypertensive rats
✍ C C Sieber; F Lee; R J Groszmann 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 210 KB

Chronically portal-hypertensive rats show in vitro vascular hyporeactivity in large part mediated by the endothelium-derived vasodilator nitric oxide. We tested whether long-term octreotide treatment (15 micrograms/kg subcutaneously in 5% D/W, 8-hourly) corrects the in vitro vascular hyporeactivity.