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Observations on the mechanism of the alkylation reaction between nitrogen mustard and DNA

✍ Scribed by Robert J. Rutman; E.H.L. Chun; J. Jones


Book ID
115743579
Publisher
Elsevier Science
Year
1969
Weight
864 KB
Volume
174
Category
Article
ISSN
0005-2787

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Alkylation of the dna of sensitive and r
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## Abstract The concentration of ^3^H‐aniline mustard in two tumour lines has been measured and the level of binding of the drug to DNA followed for 48 hours after intraperitoneal injection. Although the two tumour lines differ a hundred‐fold in their sensitivity to this alkylating agent, no good c