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Alkylation of the dna of sensitive and resistant tumours by a nitrogen mustard derivative

✍ Scribed by T. A. Connors; J. A. Double

Publisher
John Wiley and Sons
Year
1970
Tongue
French
Weight
564 KB
Volume
5
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

The concentration of ^3^H‐aniline mustard in two tumour lines has been measured and the level of binding of the drug to DNA followed for 48 hours after intraperitoneal injection. Although the two tumour lines differ a hundred‐fold in their sensitivity to this alkylating agent, no good correlation was found between the levels of alkylation of DNA or the rate of removal of drug from DNA and the sensitivity of the tumour to the agent, although 24 hours after administration of the agent the label was removed from the DNA of the resistant tumour at an unexpectedly high rate.

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