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Comparison of nitrogen-mustard-sensitive and -resistant yoshida sarcomas

โœ Scribed by C. R. Ball; T. A. Connors; J. A. Double; V. Ujhazy; M. E. Whisson

Publisher
John Wiley and Sons
Year
1966
Tongue
French
Weight
598 KB
Volume
1
Category
Article
ISSN
0020-7136

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โœฆ Synopsis

The Yoshida sarcoma and a line derived from it showing acquired resistance to alkylating agents have been compared from a number of aspects: chromosome number, growth rate, nucleic acid, protein and free thiol content. Although the degree of resistance to the alkylating agent Melphalan has been demonstrated to be at least I00 timesgreater than in the sensitive strain, the two tumours have been very similar in all aspects so far studied. A small, and not highly signiJcant, increase in glutathione content of the solid resistant tumour has been the only diference so far demonstrated.

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