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Mechanism of resistance of yoshida sarcoma to nitrogen mustard. III. Mechanism of supressed transport of nitrogen mustard

✍ Scribed by Makoto Inaba

Publisher: John Wiley and Sons
Year: 1973
Tongue: French
Weight: 403 KB
Volume: 11
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910110127

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✦ Synopsis

Mechanism of decreased transport of nitrogen mustard ( H N , ) in HN,-resistant Yorhida sarcoma cells was investigated. H N , uptake by Yoshida sarcoma cells proved to be temperature sensitive, saturable, affected by metabolic inhibitors, and also repressed competitively by choline chloride. In resistant cells, the uptake of choline was markedly depressed. Kinetics of choline transport in resistant cells was comparatively examined, and decreased V,, and increased K , were observed in some resistant sublines. Accordingly,decrease in choline uptake may be due to decreased activity of choline transport-carrier, both qualitatively and quantitatively. Decreased H N , uptake by resistant cells seemed to be produced by the same mechanism.

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