A comparative study of the bactericidal effect of photocatalytic oxidation by TiO2 on antibiotic-resistant and antibiotic-sensitive bacteria
✍ Scribed by Ting-Mi Tsai; Hsin-Hou Chang; Kia-Chih Chang; Yu-Lin Liu; Chun-Chieh Tseng
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 2010
- Tongue
- English
- Weight
- 656 KB
- Volume
- 85
- Category
- Article
- ISSN
- 0268-2575
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✦ Synopsis
Abstract
BACKGROUND: In recent decades, the increase in antibiotic‐resistant bacteria has become one of the most significant problems in public health. Titanium dioxide (TiO~2~) has the potential to inactivate antibiotic‐resistant bacteria.
RESULTS: In this study, TiO~2~ that had been activated by ultraviolet A (UV‐A) irradiation was used to inactivate the following three antibiotic‐resistant bacteria in suspension: methicillin‐resistant Staphylococcus aureus (MRSA), multidrug‐resistant Acinetobacter baumannii (MDRAB) and vancomycin‐resistant Enterococcus faecalis (VRE). For comparison, the following antibiotic‐sensitive strains were used as controls: S. aureus (MSSA), A. baumannii (MDSAB), E. faecalis (VSE), Escherichia coli and the bacteriophage MS2. Results demonstrated that MSSA and MRSA were equally susceptible to TiO~2~ photocatalysis, and the susceptibility of MDRAB was double that of MDSAB (P < 0.05). The susceptibility of VSE was 2.4 times that of VRE (P < 0.05). The results obtained from multiple regression analysis indicated that TiO~2~ reaction time had the greatest influence on microbial survival following TiO~2~ exposure in the presence of UV‐A.
CONCLUSION: The development of antibiotic resistance does not appear to be correlated to increased resistance to TiO~2~ photocatalysis, but TiO~2~ in the presence of UV‐A still effectively reduces the number of antibiotic‐resistant microbes in suspension by 1–3 logs. Copyright © 2010 Society of Chemical Industry