O6-Alkylguanine-DNA alkyltransferase activity of human malignant glioma and its clinical implications
β Scribed by Takuhiro Hotta; Yuji Saito; Hiroshi Fujita; Takashi Mikami; Kaoru Kurisu; Katsuzo Kiya; Tohru Uozumi; Gohei Isowa; Kanji Ishizaki; Mitsuo Ikenaga
- Publisher
- Springer US
- Year
- 1994
- Tongue
- English
- Weight
- 475 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0167-594X
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O 6 -Alkylguanine-DNA-alkyltransferase (ATase) is an important modulator of alkylating agent-induced toxicity and carcinogenicity, but those factors which influence the expression of this repair protein in human tissues are poorly characterised. In this study, we have determined ATase levels in macr
## Abstract __O__^6^βAlkylguanineβDNA alkyltransferase (ATase) activity was determined in crude sonicates of tissues obtained from the F2 offspring of human ATase transgenic founder mice. In certain cases, samples were analyzed both before and after administration of zinc sulfate in the drinking wa