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Numerical chromosomal aberrations in thyroid tumors detected by double fluorescence in situ hybridization

✍ Scribed by Dr. Domenica Taruscio; Thomas Ried; David C. Ward; Maria Luisa Carcangiu

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
506 KB
Volume
9
Category
Article
ISSN
1045-2257

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✦ Synopsis

Double fluorescence in situ hybridization with D N A probes specific for the (peri)centromeric regions of chromosomes 3, 7, 9, I I, 12, 18, and X was performed on fresh isolated nuclei and frozen tissue sections prepared from 2 nodular hyperplasias, 2 adenomas, and 7 papillary carcinomas of the thyroid in order to detect numerical chromosomal changes. Numerical chromosomal aberrations were found in all malignant specimens examined. A consistent presence of at least two trisomies was detected in most cases, especially in the follicular variant specimens; the highest degree of trisomy was observed for chromosome 12. Isolated monosomies of moderate degree for different chromosomes were found in I adenoma and 2 papillary carcinomas. Severe monosomy of chromosome 9 was the only significant feature observed in the single metastatic papillary carcinoma. Genes Chrorn Cancer 9:180-185 (1994).

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