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Minute chromosomal rearrangements detected prenatally by fluorescence in situ hybridization

✍ Scribed by Kaoru Suzumori; Mitsuyo Tanemura; Naomi Oya; Nobuhiro Suzumori; Kyoung Chang Kim; Hirofumi Ohashi; Yoshimitsu Fukushima

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 236 KB
Volume: 18
Category: Article
ISSN: 0197-3851
DOI: 10.1002/(sici)1097-0223(199807)18:7<725::aid-pd323>3.0.co;2-6

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✦ Synopsis

Initial approaches to prenatal diagnosis from fetal karyotyping involved application of standard cytogenetic techniques. However, when fetal samples, such as chorionic villus cells or amniocytes are used, small chromosome rearrangements cannot be easily identified because they lack a distinct banding pattern. We report here two cases with minute chromosome rearrangements detected prenatally by fluorescence in situ hybridization.

The use of this technique allowed precise identification of fetal chromosome abnormalities, demonstrating its usefulness for characterizing conditions that would be difficult to diagnose correctly with conventional banding methods alone. 1998 John Wiley & Sons, Ltd.

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