𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Low frequency of numerical chromosomal aberrations in follicular thyroid tumors detected by comparative genomic hybridization

✍ Scribed by Tony Frisk; Soili Kytölä; Göran Wallin; Jan Zedenius; Catharina Larsson

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
110 KB
Volume
25
Category
Article
ISSN
1045-2257

No coin nor oath required. For personal study only.

✦ Synopsis

Follicular thyroid tumors vary from adenomas to widely invasive carcinomas, and a stepwise progression from normal thyrocyte to malignant tumor has been suggested to be due to an accumulation of genetic alterations. We have used comparative genomic hybridization to screen 21 follicular thyroid tumors (8 adenomas and 13 carcinomas) for gains and losses of DNA sequence copy numbers. In general, the tumors showed few alterations involving several different chromosomal regions. The frequency of alterations was similar in the benign (mean, 1.9) and malignant (mean, 1.5) tumors, as well as in minimally (mean, 1.5) and widely invasive carcinomas (mean, 1.6). However, specific loss of 9q13-q21.3 was detected in three tumors, which were all carcinomas showing oxyphilic changes (Hu ¨rthle cell carcinomas; P ϭ 0.003). The fact that DNA copy number alterations were found with a similarly low frequency in both benign and malignant follicular thyroid tumors does not support the hypothesis of a multistep tumor progression in these tumors.

📜 SIMILAR VOLUMES

Detection of numerical chromosome aberra
Detection of numerical chromosome aberrations by comparative genomic hybridization
✍ M. Daniely; G. Barkai; B. Goldman; A. Aviram-Goldring 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 215 KB 👁 2 views

At least 50 per cent of all first-trimester spontaneous abortions are cytogenetically abnormal, including trisomy, monosomy X, triploidy, tetraploidy and structural chromosome anomalies. Traditionally, the detection of aneuploidy in fetal tissues is performed by tissue sampling, cell culturing, meta

1p and 3p deletions in meningiomas witho
1p and 3p deletions in meningiomas without detectable aberrations of chromosome 22 identified by comparative genomic hybridization
✍ Katrin M. Carlson; Carl Bruder; Magnus Nordenskjöld; Jan P. Dumanski 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 78 KB 👁 1 views

Meningioma is a common tumor of the meninges covering the central nervous system. Although generally a benign tumor, meningioma often recurs and is malignant in 5-10% of all cases. Loss of chromosome 22 loci, and specifically inactivation of the NF2 tumor suppressor gene, is considered one of severa