A series of novel 2 0 -deoxy-2 0 -a-fluoro-2 0 -b-C-methyl 3 0 ,5 0 -cyclic phosphate nucleotide prodrug analogs were synthesized and evaluated for their in vitro anti-HCV activity and safety. These prodrugs demonstrated a 10-100-fold greater potency than the parent nucleoside in a cell-based replic
✦ LIBER ✦
Nucleotide Prodrugs of 2′-Deoxy-2′-spirooxetane Ribonucleosides as Novel Inhibitors of the HCV NS5B Polymerase
✍ Scribed by Jonckers, Tim H. M.; Vandyck, Koen; Vandekerckhove, Leen; Hu, Lili; Tahri, Abdellah; Van Hoof, Steven; Lin, Tse-I; Vijgen, Leen; Berke, Jan Martin; Lachau-Durand, Sophie; Stoops, Bart; Leclercq, Laurent; Fanning, Gregory; Samuelsson, Bertil; Nilsson, Magnus; Rosenquist, Åsa; Simmen, Kenny; Raboisson, Pierre
- Book ID
- 121444484
- Publisher
- American Chemical Society
- Year
- 2014
- Tongue
- English
- Weight
- 437 KB
- Volume
- 57
- Category
- Article
- ISSN
- 0022-2623
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