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Nucleotide Prodrugs of 2′-Deoxy-2′-spirooxetane Ribonucleosides as Novel Inhibitors of the HCV NS5B Polymerase

✍ Scribed by Jonckers, Tim H. M.; Vandyck, Koen; Vandekerckhove, Leen; Hu, Lili; Tahri, Abdellah; Van Hoof, Steven; Lin, Tse-I; Vijgen, Leen; Berke, Jan Martin; Lachau-Durand, Sophie; Stoops, Bart; Leclercq, Laurent; Fanning, Gregory; Samuelsson, Bertil; Nilsson, Magnus; Rosenquist, Åsa; Simmen, Kenny; Raboisson, Pierre


Book ID
121444484
Publisher
American Chemical Society
Year
2014
Tongue
English
Weight
437 KB
Volume
57
Category
Article
ISSN
0022-2623

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✍ P. Ganapati Reddy; Donghui Bao; Wonsuk Chang; Byoung-Kwon Chun; Jinfa Du; Dhanap 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 808 KB

A series of novel 2 0 -deoxy-2 0 -a-fluoro-2 0 -b-C-methyl 3 0 ,5 0 -cyclic phosphate nucleotide prodrug analogs were synthesized and evaluated for their in vitro anti-HCV activity and safety. These prodrugs demonstrated a 10-100-fold greater potency than the parent nucleoside in a cell-based replic