𝔖 Bobbio Scriptorium
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Nucleosides. VIII. Synthesis of 2′,3′-unsaturated pyrimidine nucleosides from oxetane derivatives

✍ Scribed by J.P. Horwitz; J. Chua; M.A. Da Rooge; M. Noel


Publisher
Elsevier Science
Year
1964
Tongue
French
Weight
105 KB
Volume
5
Category
Article
ISSN
0040-4039

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The synthesis of 4-amino-7-(8-D-ribofuranosyl)-furoC3.2-dlpyrimidine, a new Cnucleoside analog of adenosine. is described. It involves base-catalyzed cyclization of the 2-(ribofuranosyl)-t-cyan0 ethers 3 to afford the ribosyl-3-amino-2-cyanofurans 4a and 48. followed by a two step conversion into th