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Nucleosides LXXXIX. Synthesis of 1-(2-chloro-2-deoxy-α- and -β-D-arabinofuranosyl)cytosines

✍ Scribed by Goetz Ritzmann; Robert S. Klein; David H. Hollenberg; Jack J. Fox


Book ID
108308905
Publisher
Elsevier Science
Year
1975
Tongue
English
Weight
829 KB
Volume
39
Category
Article
ISSN
0008-6215

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The reaction of [2-14C]-2 ,4-bis-O-(trimethylsilyl)uracil (2) with ~-~-acetyl-~-0-benzoyl-2-deoxy-2-fluoro-~-D-arabinofuranosyl bromide (3) yielded the 3-O-acety1-5-0-benzoyl nucleos e 4 which was hydrolyzed with methanolic ammonia to afford [ 2-feC]-T-( 2-deoxy-2fluoro-p-D-arabinofuranosy1)uracil (