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Antitumor activity of a novel orally effective nucleoside, 1-(2-deoxy-2-fluoro-4-thio-β-d-arabinofuranosyl)cytosine

✍ Scribed by Shinji Miura; Yuichi Yoshimura; Mikari Endo; Haruhiko Machida; Akira Matsuda; Motohiro Tanaka; Takuma Sasaki


Book ID
117469075
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
170 KB
Volume
129
Category
Article
ISSN
0304-3835

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## Abstract 1‐(2‐Deoxy‐2‐fluoro‐4‐thio‐β‐D‐arabinofuranosyl) cytosine (4′‐thio‐FAC) is a deoxycytidine analog that has been shown previously to have impressive anti‐proliferative and cytotoxic effects __in vitro__ and __in vivo__ toward colorectal and gastric tumors. In our present studies, the pha