The Antitumor Mechanism of 1-(2-Deoxy-2-fluoro-4-thio-β-D-arabinofuranosyl)-cytosine: Effects of Its Triphosphate on Mammalian DNA Polymerases
✍ Scribed by Miura, Shinji ;Yoshimura, Yuichi ;Satoh, Hiroshi ;Izuta, Shunji
- Book ID
- 108582021
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2001
- Tongue
- English
- Weight
- 125 KB
- Volume
- 92
- Category
- Article
- ISSN
- 0910-5050
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## Abstract 1‐(2‐Deoxy‐2‐fluoro‐4‐thio‐β‐D‐arabinofuranosyl) cytosine (4′‐thio‐FAC) is a deoxycytidine analog that has been shown previously to have impressive anti‐proliferative and cytotoxic effects __in vitro__ and __in vivo__ toward colorectal and gastric tumors. In our present studies, the pha
Selective uptake of nucleoside analogues by herpes simplex virus infected cells may serve as the basis for a specific non-invasive diagnostic test for herpes simplex encephalitis. We have examined the effect of acyclovir on the selective uptake of [131I] 1-(2'-fluoro-2'-deoxy-beta-D-arabinofuranosyl