Primary and secondary amines react rapidly with perfluoro-and halofluoroolefins to give aminofluoroalkanes and fluorovinylamines by addition and additiou-elimination reactions.' We report here on the reaction of se"-era1 alkoxyfluorocycloolefins with primary and secondary amines to give alkylamino-u
Nucleophilic substitution reaction in polyfluoroaromatics: I. Reactions with secondary amine nucleophiles
β Scribed by Wen-Zheng Ge; Bao-Ming Wu; Wei-Yuan Huang
- Book ID
- 112058600
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- English
- Weight
- 464 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0256-7660
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A novel formaldehyde-mediated condensation reaction of N,N-dialkyl aromatic amines and resonance-stabilized carbon nucleophiles is described. A condensation reaction between N,N-dimethylaniline (4) and ethyl acetoacetate (8) in the presence of formaldehyde in acetic acid took place to give 2-(4-dime
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## Abstract magnified image The highly functionalized heterocycles 6βalkylβ respectively 6βaralkylsulfanylβ2,4βbisβ(amidomethylsulfanyl) pyrimidineβ5βcarbonitriles react selective in the 2βposition with various secondary cyclic amines under mild conditions. The resulting pyrimidines were finally t