𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Selective nucleophilic substitution reactions in 2,4,6-trisulfanyl-substituted pyrimidine-5-carbonitriles by secondary amines

✍ Scribed by Simon Drescher; Daniel Ramsbeck; Bodo Dobner; Detlef Briel

Book ID
102339250
Publisher
Journal of Heterocyclic Chemistry
Year
2007
Tongue
English
Weight
402 KB
Volume
44
Category
Article
ISSN
0022-152X

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

magnified image

The highly functionalized heterocycles 6‐alkyl‐ respectively 6‐aralkylsulfanyl‐2,4‐bis‐(amidomethylsulfanyl) pyrimidine‐5‐carbonitriles react selective in the 2‐position with various secondary cyclic amines under mild conditions. The resulting pyrimidines were finally transformed into the corresponding thieno[2,3‐d]pyrimidine‐6‐carboxylic acid amides which afford the synthesis of selective substituted thienopyrimidines.

📜 SIMILAR VOLUMES

Selective Nucleophilic Substitution Reac
Selective Nucleophilic Substitution Reactions in 2,4,6-Trisulfanyl-Substituted Pyrimidine-5-carbonitriles by Secondary Amines.
✍ Simon Drescher; Daniel Ramsbeck; Detlef Briel; Bodo Dobner 📂 Article 📅 2007 🏛 John Wiley and Sons ⚖ 25 KB

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

Selective nucleophilic replacement of th
Selective nucleophilic replacement of the benzylsulfanyl group in 2,4-disulfanyl-substituted thieno[2,3-d]pyrimidin-6-carboxylic acid derivatives by secondary amines
✍ Detlef Briel; Simon Drescher; Bodo Dobner 📂 Article 📅 2005 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 102 KB

## Abstract Thieno[2,3‐__d__]pyrimidines with benzylsulfanyl and allylsulfanyl group in the presence of other alkylsul‐fanyl substituents react selectively under mild conditions with secondary amines under replacement of the benzyl or allyl residue whereas the other substituents remain intact. This