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Selective nucleophilic replacement of the benzylsulfanyl group in 2,4-disulfanyl-substituted thieno[2,3-d]pyrimidin-6-carboxylic acid derivatives by secondary amines

✍ Scribed by Detlef Briel; Simon Drescher; Bodo Dobner

Publisher: Journal of Heterocyclic Chemistry
Year: 2005
Tongue: English
Weight: 102 KB
Volume: 42
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570420514

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✦ Synopsis

Abstract

Thieno[2,3‐d]pyrimidines with benzylsulfanyl and allylsulfanyl group in the presence of other alkylsul‐fanyl substituents react selectively under mild conditions with secondary amines under replacement of the benzyl or allyl residue whereas the other substituents remain intact. This enables the synthesis of different basic substituted derivatives with potentially biologically activity.

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