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Nucleophilic Acylation of o-Quinone Methides: An Umpolung Strategy for the Synthesis of α-Aryl Ketones and Benzofurans
✍ Scribed by Mattson, Anita E.; Scheidt, Karl A.
- Book ID
- 111919377
- Publisher
- American Chemical Society
- Year
- 2007
- Tongue
- English
- Weight
- 67 KB
- Volume
- 129
- Category
- Article
- ISSN
- 0002-7863
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📜 SIMILAR VOLUMES
The first example of N-heterocyclic carbene (NHC)-promoted intermolecular acylation of a-haloketones with aldehydes and a,b-unsaturated aldehydes (enals) is reported. The protocol involves carbonyl umpolung reactivity of aldehydes and enals in which the carbonyl carbon attacks nucleophilically on el
2005 ## Amines Q 0120 Catalytic Additions of Acylsilanes to Imines: An Acyl Anion Strategy for the Direct Synthesis of α-Amino Ketones. -The title methodology enables direct formation of N-phosphinylated amino ketones and completely avoids benzoin formation. The reaction tolerates structural div