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Catalytic Additions of Acylsilanes to Imines: An Acyl Anion Strategy for the Direct Synthesis of α-Amino Ketones.

✍ Scribed by Anita E. Mattson; Karl A. Scheidt

Publisher: John Wiley and Sons
Year: 2005
Weight: 25 KB
Volume: 36
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200511091

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✦ Synopsis

2005

Amines Q 0120

Catalytic Additions of Acylsilanes to Imines: An Acyl Anion Strategy for the Direct Synthesis of α-Amino Ketones. -The title methodology enables direct formation of N-phosphinylated amino ketones and completely avoids benzoin formation.

The reaction tolerates structural diversity on the acylsilane or imine. Acylsilanes with α-branching require higher catalyst loadings and longer reaction times to undergo complete conversion. -(MATTSON, A.

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