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Nuclear DNA content and p53 immunostaining in metachronous preneoplastic lesions and subsequent carcinomas of the oral cavity

✍ Scribed by Anders Högmo; Eva Munck-Wikland; Richard Kuylenstierna; Johan Lindholm; Gert Auer

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
673 KB
Volume
18
Category
Article
ISSN
1043-3074

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✦ Synopsis

Background. Clinical evaluation of preneoplastic lesions of the oral cavity is difficult. Histopathologic grading of dysplasias shows large variability and does not give reliable information concerning the risk for progression to cancer.

Methods. DNA image cytometry and p53 irnmunostaining were performed to describe the pattern of DNA aberration and p53 overexpression in confined preneoplastic lesions and in the subsequent carcinomas developing at the same site in 20 patients.

Results. Hyperplastic and/or inflammatory lesions showed a diploid DNA pattern in 81% of the cases and 23% were p53positive. Dysplastic preneoplastic lesions showed a nondiploidl aneuploid DNA pattern in 73% and 64% were p53-positive. The subsequent invasive carcinomas were nondiploid/aneuploid in 86% and p53-positive in 69% of cases.

Conclusions. Analysis of nuclear DNA content and p53 imrnunostaining appears to be useful as an adjunct to histopathology in the evaluation of true precancerous lesions.

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