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Novel variants of the human flavin-containing monooxygenase 3 (FMO3) gene associated with trimethylaminuria

✍ Scribed by Meike S. Motika; Jun Zhang; Xueying Zheng; Kiersten Riedler; John R. Cashman

Book ID: 116988638
Publisher: Elsevier Science
Year: 2009
Tongue: English
Weight: 594 KB
Volume: 97
Category: Article
ISSN: 1096-7192
DOI: 10.1016/j.ymgme.2009.02.006

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The mammalian flavin-containing monooxygenases catalyze the NADPH-dependent N-oxygenation of nucleophilic nitrogen-, sulfur-, and phosphorus-containing chemicals, drugs, and xenobiotics, including trimethylamine. The FMO3 gene encodes the dominant catalytically active isoform present in human liver.