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A novel mutation in the flavin-containing monooxygenase 3 gene (FMO3) of a Norwegian family causes trimethylaminuria

โœ Scribed by C.K. Allerston; H.H. Vetti; G. Houge; I.R. Phillips; E.A. Shephard


Book ID
116988676
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
443 KB
Volume
98
Category
Article
ISSN
1096-7192

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The mammalian flavin-containing monooxygenases catalyze the NADPH-dependent N-oxygenation of nucleophilic nitrogen-, sulfur-, and phosphorus-containing chemicals, drugs, and xenobiotics, including trimethylamine. The FMO3 gene encodes the dominant catalytically active isoform present in human liver.